IACS eXplorer
Description
IACS eXplorer from Sensific is a compact, fully integrated Image-Activated Cell Sorting (IACS) platform that enables real-time, image-based analysis and sorting of cells, droplets, and particles. By combining high-speed imaging, intelligent image analysis, and precise microfluidic sorting, IACS eXplorer allows researchers to sort based on true visual phenotypes rather than signal intensity alone. The system is ideal for advanced single-cell analysis, functional assays, and exploratory research where conventional sorting methods reach their limits.
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Product description
IACS eXplorer from Sensific is a compact, fully integrated Image-Activated Cell Sorting (IACS) platform that enables real-time, image-based analysis and sorting of cells, droplets, and particles. By combining high-speed imaging, intelligent image analysis, and precise microfluidic sorting, IACS eXplorer allows researchers to sort based on true visual phenotypes rather than signal intensity alone. The system is ideal for advanced single-cell analysis, functional assays, and exploratory research where conventional sorting methods reach their limits.
Features
| Sorting Method | Active Dielectrophoretic |
| Sorting Efficiency, Selectivity, Purity | Up to 99 % demonstrated |
| Droplet Sizes | 10 µm to 1 mm diameter |
| Detection Methods | Bright field image; Phase contrast image; Fluorescence 408 nm image; Fluorescence 488 nm image; Fluorescence 532 nm image; Fluorescence 561 nm image; Fluorescence 638 nm image |
| Detection Parameters | Brightness/intensity; brightness contrast; circumference; area; surface roughness; colocalization; fluorescence colocalization; particle count; area contrast; fill factor; elongation; circularity; size; velocity; position; granularity; removal of small dirt particles; area of no contrast; contrast within particles; particles touching walls; particles touching image boundaries; particle position; particle velocity |
| Integration Options | adaptable microfluidic chips (no vendor lock); adaptable lasers; adaptable sample stages; adaptable fluorescence filter sets; inline droplet generation or reinjection; sterilization |
| Quality Control | In-line, multispectral image per particle pre & post sorting; all droplets recorded |
| Sample Viability | Further downstream usage of the sample; maximized cell viability |
| Assay-based Sorting | Yes |
Download the full IACS eXplorer Specifications in Documents.
Applications
- (Single) Cell Sorting
- (Single) Cell Analysis
- Cell Therapy
- Drug Discovery
- Drop-Seq
- (RNA) Sequencing
- Bacteria Analysis & Sorting
- Algae Analysis & Sorting
- Yeast Analysis & Sorting
- Particle Analysis & Sorting
- Sperm Analysis & Sorting
- Spheroid Generation & Sorting
- Droplet Generation, Manipulation, Analysis & Sorting
Specifications
| Imaging Sensor | High-performance camera with integrated analysis and feature extraction |
| Frame Rate | 210 fps @ 1280×1024 px, up to 10000 fps @ 400×32 px, monochrome, 10bit color depth |
| Sensitivity | Wavelength range 300-1000 nm, 58% QE @ 550nm peak ; 62% QE @ 630nm; global shutter |
| Readout Regions | 2 freely selectable, simultaneous readout regions, e.g. for two stage processes, immediate quality control or parallelization |
| Latency | Image capturing to analysis result <200 microseconds, control precision <10 nanoseconds |
| Outputs | 6 flash outputs for light control; 2 trigger for sorting / device control (3.3V TTL) |
| Interfacing | C-mount; Ethernet; DVI-D; USB |
| Software | User-friendly and feature-rich graphical user-interface for observation, analysis, and control |
| Analysis | Real-time analysis of various detection parameters like size, velocity, position, granularity, circumference etc. |
| Gating | Freely configurable gating; graphical marking in scatter plot; arbitrary points polygon |
| Triggers | Freely programmable and independent triggers; latency down to 200µs (frame rate dependent) |
| Storage Format | RAW; AVI uncompressed; MJPEG; MP4; XLS; XLSX; CSV (infinite recording) |
| Multi-Color | Up to 4 simultaneous imaging settings by time multiplexing (e.g. bright field and three different fluorescent colors) |
| Flow Control | Precise control of flow and droplets via software-based closed-loop feedback |
| Pressure Control | 4 channels, up to 2000 mbar |
| Droplet Parameters | Supports droplet diameters from tens to hundreds of micrometers, with tunable size and generation frequency. |
| All-in-one Solution | Fully integrated and automated analysis system |
| Microscope | Fully automized microscope (XYZ stage) featuring fully corrected and automized Köhler optics; motorized four-position objective turret |
| Sample Holder | Easy-access sample holder stage for Sensific sample holders or chips and open compatibility. Accommodates up to six microfluidic reservoirs (1.5 mL, 2 mL or 15 mL). Other sample holders on request. |
| Laser saftey | Laser proof casing with interlock for Class 1 laser safety rating and electric shock hazard mitigation. |
| Size (L*W*H/mm) | 690 x 400 x 530 (compatible with most laminar flow systems) |
Download the full IACS eXplorer Specifications in Documents.
