Product description

Dihydropyrimidine dehydrogenase (DPD) is an enzyme encoded by the DPYD gene and is involved in the metabolism of fluoropy- rimidines, chemotherapeutics used in the treatment of some solid tumors. These drugs can cause severe gastrointestinal and hematologic toxicities due to the presence of certain mutations of the DPYD gene that determine the reduced activity of the encoded enzyme. Investigating these mutations before starting treatment helps physicians to determine the optimal dose of the drug and reduces the risk of toxicity.

Size: 25 tests

Features

• A multiplex real-time PCR that allows amplification of wild-type and mutant nucleic acids.
• Allele Specific Realtime PCR (Aso-Realtime PCR)
• Compatible with FAM and VIC/HEX dual color real-time PCR instruments.
• CE-IVD
• Real-time PCR

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